A regressão logística multivariada encontrou, inicialmente, associação entre aumento absoluto da SCr ≥ 0,3 mg/dL após TC e idade avançada, mas a associação não foi mantida após correção. A regressão logística univariada demonstrou significância relacionada à associação entre aumento absoluto da SCr ≥ 0,5 mg/dL após TC e lesão renal aguda. RESULTADOS: A incidência de lesão renal aguda foi de 11,52% aplicando os critérios KDIGO. O desfecho primário foi nefropatia induzida por contraste, definida pelo critério antigo – aumento absoluto ou relativo na creatinina sérica (SCr) ≥ 0,5 mg/dL ou ≥ 25%, respectivamente, durante 2–3 dias após a administração –, e o novo, Kidney Disease Improving Global Outcomes (KDIGO) – aumento absoluto ou relativo na SCr ≥ 0,3 mg/dL ou ≥ 50%, respectivamente, durante 2–7 dias após a administração. MATERIAIS E MÉTODOS: Estudo de coorte retrospectivo que alocou 1.238 pacientes submetidos a TC sem ou com contraste (iopromida). OBJETIVO: Determinar a incidência de nefropatia induzida por contraste intravenoso em pacientes hospitalizados submetidos a tomografia computadorizada (TC). We found no association between AKI and the risk factors evaluated.ĬONCLUSION: We identified no criteria for contrast-induced nephropathy after CT nor did we find AKI to be associated with the classical risk factors. Multivariate logistic regression initially found an association between an absolute post-CT increase in SCr ≥ 0.3 mg/dL and advanced age, although that association was not maintained after correction. Univariate logistic regression demonstrated a significant association between an absolute post-CT increase in SCr ≥ 0.5 mg/dL and AKI, although that association did not retain significance in the multivariate analysis. RESULTS: The overall incidence of AKI was 11.52% when the KDIGO criteria were applied. The primary outcome measure was acute kidney injury (AKI), as defined by the traditional criteria-an absolute or relative increase in serum creatinine (SCr) ≥ 0.5 mg/dL or ≥ 25% over baseline, respectively, at 2–3 days after contrast administration-and the newer, Kidney Disease: Improving Global Outcomes (KDIGO) criteria-an absolute or relative increase in SCr ≥ 0.3 mg/dL or ≥ 50% over baseline, respectively, at 2–7 days after contrast administration. MATERIALS AND METHODS: This was a retrospective cohort study involving 1,238 patients who underwent CT with or without intravenous administration of a contrast agent (iopromide). OBJECTIVE: To determine the incidence of nephropathy induced by intravenous contrast in hospitalized patients undergoing computed tomography (CT). Keywords: Acute kidney injury Tomography, X-ray computed Contrast media/adverse effects Contrast media/administration & dosage Iodine radioisotopes Creatinine/blood.ĭescritores: Lesão renal aguda Tomografia computadorizada Meios de contraste/efeitos adversos Meios de contraste/administração & dosagem Radioisótopos do iodo Creatinina/sangue. Intravenous contrast use and acute kidney injury: a retrospective study of 1,238 inpatients undergoing computed tomographyĪutho(rs): Thyago A.
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